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Detailed Project Description
Genetics of Type II Diabetes.
Background
Type II Diabetes is a multifactorial autoimmune/metabolic disease characterized by hyperglycemia, insulin resistance and relative impairment in insulin secretion. The prevalence of Type II Diabetes in adults is increasing and is highly correlated with the degree of an individual’s obesity. At present, approximately 7% of all Canadians have Type II Diabetes. While clinical studies demonstrate that Type II Diabetes has a strong genetic component, it is also influenced by environmental factors. However, there is still little known about the Type II Diabetes phenotype in Newfoundland, predictive factors for complications and its genetic basis. Both direct and indirect costs associated with diabetes account for a substantial portion of the national health care budget.
Primary Objectives
The primary objective of this study is to recruit patients with Type II Diabetes and investigate candidate chromosomal regions using transmission disequilibrium approaches. A genome wide search will also be attempted to elucidate novel disease related genes through traditional and sibling pair approaches.
Study Updates - Refer back to this page regularly to review updates specific to this study.
Because Newfound Genomics must rely on the involvement of donor volunteers, you can make a difference. If you or a family member has Type II Diabetes, your genetic information encoded within your DNA could help lead to a medical breakthrough! There is no cost to you, only a moment in time. Please help us help you.
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